Phospho-GluR2/GRIA2-S880 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-GluR2/GRIA2-S880 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP0257
• Supplier Catalog Number: AP0257
• Alternative Catalog Number: ABB-AP0257-100UL, ABB-AP0257-20UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: GLUR2, GLURB, GluA2, HBGR2, NEDLIB, gluR-2, gluR-B, GluR-K2, Phospho-GluR2/GRIA2-S880

Product Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Product Properties

• Concentration: WB
• Molecular Weight: 99kDa
• NCBI: 2891
• UniProt: P42262
• Purity: Affinity purification
• Target: GRIA2

Application Notes

• Application Dilute: WB,1:500 - 1:2000
• Application Notes: Cross-Reactivity: Human,Mouse,Rat, ResearchArea: Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Dopamine Signaling in Parkinsons Disease.

Images

Western blot analysis of lysates from mouse brain tissue using Phospho-GluR2/GRIA2-S880 Rabbit pAb (AP0257) and the same antibody preincubated with blocking peptide.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.