Phospho-CDKN1B/p27KIP1-T187 Rabbit pAb, Unconjugated
Catalog Number:
ABB-AP0328
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| Article Name: | Phospho-CDKN1B/p27KIP1-T187 Rabbit pAb, Unconjugated |
| Biozol Catalog Number: | ABB-AP0328 |
| Supplier Catalog Number: | AP0328 |
| Alternative Catalog Number: | ABB-AP0328-20UL,ABB-AP0328-100UL,ABB-AP0328-1000UL,ABB-AP0328-500UL |
| Manufacturer: | ABclonal |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Conjugation: | Unconjugated |
| Alternative Names: | KIP1, MEN4, CDKN4, MEN1B, P27KIP1, Phospho-CDKN1B/p27KIP1-T187 |
| This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). |
| Application Dilute: | WB,1:500 - 1:1000 |
| Application Notes: | Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,DNA Damage Repair,Cancer,Signal Transduction,Kinase,Serine threonine kinases,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Cell Cycle,Cell cycle inhibitors,Cell Cycle Control-G1 S Checkpoint,Immunology Inflammation. |
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Western blot analysis of lysates from HeLa cells, using Phospho-CDKN1B/p27KIP1-T187 Rabbit pAb (AP0328). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% BSA. |
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