Phospho-c-Myc-T358 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-c-Myc-T358 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP0411
• Supplier Catalog Number: AP0411
• Alternative Catalog Number: ABB-AP0411-20UL, ABB-AP0411-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: MRTL, MYCC, c-Myc, bHLHe39, Phospho-c-Myc-T358

Product Description

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Product Properties

• Molecular Weight: 51kDa
• NCBI: 4609
• UniProt: P01106
• Purity: Affinity purification
• Target: MYC

Application Notes

• Application Dilute: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human, ResearchArea: Epigenetics Nuclear Signaling,Transcription Factors,Protein phosphorylation,Cancer,Tumor biomarkers,Signal Transduction,MAPK-Erk Signaling Pathway,Cell Biology Developmental Biology,Apoptosis,Cell Cycle,Cell differentiation,Cell Cycle Control-G1 S Checkpoint,Endocrine Metabolism,Warburg Effect,Immunology Inflammation,Jak-Stat-IL-6 Receptor Signaling Pathway,Stem Cells.

Images

Western blot analysis of lysates from HT-29 cells, using Phospho-c-Myc-T358 Rabbit pAb (AP0411). HT-29 cells treated with UV.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.