Phospho-STING/TMEM173-S365 Rabbit mAb, Unconjugated

Product Overview

• Article Name: Phospho-STING/TMEM173-S365 Rabbit mAb, Unconjugated
• Biozol Catalog Number: ABB-AP1580
• Supplier Catalog Number: AP1580
• Alternative Catalog Number: ABB-AP1580-500UL,ABB-AP1580-1000UL,ABB-AP1580-20UL,ABB-AP1580-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Mouse
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: ERIS, MPYS, Mita, STING, Tmem173, STING-beta, 2610307O08Rik

Product Description

Enables 2,3-cyclic GMP-AMP binding activity, cyclic-di-GMP binding activity, and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism, macroautophagy, and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta, positive regulation of transcription by RNA polymerase II, and regulation of inflammatory response. Located in several cellular components, including autophagosome, perinuclear region of cytoplasm, and peroxisome. Is expressed in ductus deferens, epididymis, ileum, and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1).

Product Properties

• Molecular Weight: 43kDa
• NCBI: 72512
• UniProt: Q3TBT3
• Purity: Affinity purification
• Sequence: LISGMD
• Target: Sting1

Application Notes

• Application Dilute: WB,1:5000 - 1:10000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Mouse, ResearchArea: Epigenetics Nuclear Signaling,Cancer,Immunology Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway.

Images

Western blot analysis of lysates from RAW 264.7 cells using Phospho-STING/TMEM173-S365 Rabbit mAb (AP1580) at 1:5000 dilutionincubated overnight at 4°C. RAW 264.7 cells were treated with Poly(dA:dT) (5 µg/mL) at 37°C for 3 hours.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 30 µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 60s.