Enables extracellular matrix binding activity and integrin binding activity. Involved in bone mineralization and calcium ion homeostasis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor, intracellular chloride ion homeostasis, and intracellular monoatomic cation homeostasis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system, brain, metanephros, sensory organ, and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple), biliary atresia, coronary artery disease (multiple), disease of cellular proliferation (multiple), and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).
