Recombinant Human TNFSF11/RANKL/CD254 Protein

Product Overview

• Article Name: Recombinant Human TNFSF11/RANKL/CD254 Protein
• Biozol Catalog Number: ABB-RP00183S
• Supplier Catalog Number: RP00183S
• Alternative Catalog Number: ABB-RP00183S-10UG, ABB-RP00183S-20UG, ABB-RP00183S-100UG, ABB-RP00183S-50UG
• Manufacturer: ABclonal
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Immunogen: Gly136-Asp317
• Alternative Names: TNFSF11, OPGL, RANKL, TRANCE,Tumor necrosis factor ligand superfamily member 11

Product Description

Tumor necrosis factor ligand superfamily member 11, also known as Receptor activator of nuclear factor kappa-B ligand, Osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, is a single-pass type II membrane protein which belongs to the tumor necrosis factor family. TNFSF11 is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. TNFSF11 was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy.

Product Properties

• Concentration: < 0.01 EU/µg of the protein by LAL method.
• Molecular Weight: 49.2 KD
• NCBI: 8600
• UniProt: O14788
• Form: Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
• Target: TNFSF11, OPGL, RANKL, TRANCE

Application Notes

• Application Dilute: Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
• Application Notes: Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine receptors

Images

Recombinant Human TNFSF11/RANKL/CD254 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.