WIF (Wnt Inhibitory Factor) is a secreted protein that binds to Wnt proteins and inhibits their activity. WIF is extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation.. WIF-1 is implicated as an early event tumor suppressor in cancers of the prostate, breast, lung and bladder. However, WIF-1s role in carcinogenesis may not be that simple since in other cancer types, such as colon adenocarcinoma, WIF facilitates tumorigenesis.
Lyophilized from a 0.22 µm filtered solution of 20mM HAc-NaAc,150mM NaCl,0.5% CHAPS, pH 6.0.Contact us for customized product form or formulation.
Target:
WIF-1(Q166K)
Application Dilute:
Lyophilized from a 0.22 µm filtered solution of 20mM HAc-NaAc,150mM NaCl,0.5% CHAPS, pH 6.0.Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human WIF-1(Q166K) Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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