This protein belongs a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis.
Lyophilized from a 0.2 µm filtered solution of 4 mM HCl.Contact us for customized product form or formulation.
Target:
GDF-5/BMP-14
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of 4 mM HCl.Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100µg/ml. Dissolve the lyophilized protein in 4mM HCl. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. , ResearchArea: Cytokines & Cytokine Receptors
Recombinant Human GDF-5/BMP-14 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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