Inducible co-stimulator ligand (ICOSL) is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.
Lyophilized from a 0.2 µm filtered solution of PBS,pH7.4.
Target:
ICOSLG/B7-H2/CD275
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of PBS,pH7.4.
Application Notes:
Cross-Reactivity: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water., ResearchArea: Immune Checkpoint,Bio-Markers & CD Antigens
Recombinant Human B7-H2/ICOSLG/CD275 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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