Recombinant Human Tissue-type plasminogen activator/TPA/PLAT Protein
Biozol Catalog Number:
ABB-RP00595
Supplier Catalog Number:
RP00595
Alternative Catalog Number:
ABB-RP00595-10UG, ABB-RP00595-50UG
Manufacturer:
ABclonal
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Immunogen:
Ser36-Pro562
Alternative Names:
PLAT,T-PA,TPA, TPA
Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains:EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLATplays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulatingthe post-translational activation of growth factors. PLAT is found not only in the blood, where its primary function is as athrombolytic enzyme, but also in the central nervous system (CNS). It participates in a number of physiological andpathological events in the CNS, as well as the role of neuroserpin as the natural regulator of PLATs activity in theseprocesses. Increased or decreased activity of PLAT leads to hyperfibrinolysis or hypofibrinolysis, respectively. In addition, asa cytokine, PLAT plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as afibrogenic cytokine, it promotes the progression of kidney diseases.
Lyophilized from a 0.2 µm filtered solution of 20mM MES,150mM NaCl,0.2mM CaCl2, pH5.5. Contact us for customized product form or formulation.
Target:
tPA/Tissue-type plasminogen activator/PLAT
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of 20mM MES,150mM NaCl,0.2mM CaCl2, pH5.5. Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine Receptors
Recombinant Human Tissue-type plasminogen activator/TPA/PLAT Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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