Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family, contains 140 amino acids. Itis known to play an important role in the maturation of T cell populations through activation of antigenpresenting cells. TSLP induces the release of T-cell-attracting chemokines from monocytes and, in particular,enhances the maturation of CD11c+ dendritic cells. It can induce allergic inflammation by directly activatingmast cells. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and differenttypes of stromal or stromal-like cells. These cells are located in regions where TSLP activity is required.
