Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor beta 1 (IL12R beta 1) and IL12R beta 2, is a type Icytokine receptor for IL23. IL23R is comprised of two subunits, the IL12R beta 1 subunit, which is shared withseveral cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cellsand mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphismsof the IL23R gene were reported to be associated with susceptibility to inflammatory diseases andautoimmune diseases such as psoriasis, multiple sclerosis, Gravess ophtalmopathy and inflammatory boweldiseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4Contact us for customized product form or formulation.
Target:
IL-23R
Application Dilute:
Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Interleukin
Recombinant Mouse IL-23R Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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