Recombinant Mouse Fc gamma RI/FCGR1/CD64 Protein, Human
Biozol Catalog Number:
ABB-RP00710
Supplier Catalog Number:
RP00710
Alternative Catalog Number:
ABB-RP00710-10UG, ABB-RP00710-50UG
Manufacturer:
ABclonal
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Immunogen:
Glu25-Pro297
Alternative Names:
High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, CD64, Fcgr1
CD64, also known as Fc-gamma receptor 1 (Fc gamma RI), is a type of integral membrane glycoprotein that bindsmonomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chainknown as the common gamma chain (gamma chain), which possesses an ITAM motif that is necessary for triggering cellularactivation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-typeused to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediatesendocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxideproduction. It is normally expressed on the surfaces of monocytes and macrophages.
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Target:
Fc-gamma RI/CD64
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Fc & Fc Receptor
Recombinant Mouse Fc gamma RI/FCGR1/CD64 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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