Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)
Lyophilized from 0.22µm filtered solution in 50mM Acetate-sodium acetate pH3.6 .
Target:
Ccl3, Mip1a, Scya3
Application Dilute:
Lyophilized from 0.22µm filtered solution in 50mM Acetate-sodium acetate pH3.6 .
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine receptors
Recombinant Mouse CCL3/MIP-1 alpha Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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