GAPDH is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimers disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinsons disease, binds to GAPDH and displays neuroprotective actions.
Lyophilized from 0.22µm filtered solution in PBS (pH 7.4).
Target:
GAPDH, GAPD, CDABP0047, OK/SW-cl.12
Application Dilute:
Lyophilized from 0.22µm filtered solution in PBS (pH 7.4).
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Bio-Markers & CD Antigens
Recombinant Human GAPDH Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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