MMP2, CLG4A,72 kDa type IV collagenase, EC:3.4.24.24, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, Cleaved into: PEX
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-2 (gelatinase A), a type IV collagenase, can degrade a broad range of substrates including type IV, V, VII and X collagens as well as elastin and fibronectin. It is believed to act synergistically with interstitial collagenase (MMP-1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP-2 has been shown to be associated with many connective tissue cells as well as neutrophils, macrophages and monocytes. Structurally, MMP-2 may be divided into several distinct domains: a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a fibronectin-like domain thought to play a role in substrate targeting, and a carboxyl terminal (hemopexin-like) domain containing 2 N-linked glycosylation sites.
Lyophilized from a 0.2 µm filtered solution of 150 mM NaCl, 5 mM CaCl2, 50 mM Tris, pH 7.5..Contact us for customized product form or formulation.
Target:
MMP-2
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of 150 mM NaCl, 5 mM CaCl2, 50 mM Tris, pH 7.5..Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human MMP-2 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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