Nectin-4 (PVRL4) is a type I transmembrane glycoprotein which belongs to the nectin family of Ig superfamilyproteins. It contains two Ig-like C2-type domains and one Ig-like V-type domain. PVRL4 seems to be involved incell adhesion through trans-homophilic and -heterophilic interactions, the latter including specificallyinteractions with nectin-1. It does not act as receptor for alpha-herpesvirus entry into cells. It is predominantlyexpressed in placenta, the embryo and breast carcinoma. But it is not detected in normal breast epithelium.The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17.Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomalrecessive disorder.
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4.
Target:
Nectin-4
Application Dilute:
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4.
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Mouse Nectin-4/PVRL4 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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