Tumor Necrosis Factor beta (TNF- beta ) is a secreted protein belonging to the tumor necrosis factor family. TNF- betabinds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM in homotrimeric form, binds toTNFRSF3/LTBR in heterotrimeric form with LTB. TNF- beta forms heterotrimers with lymphotoxin-beta, whichanchors TNF- beta to the cell surface. TNF- beta mediates the inflammatory, immunostimulatory, and antiviralresponse, involves in the formation of second lymphoid organs during development, has a role in apoptosis.TNF-beta is produced by lymphocytes and cytotoxic for a variety of tumor cells in vitro and in vivo.
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Target:
LTA, TNFB, TNFSF1
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine receptors
Recombinant Human TNF-beta Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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