B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
Target:
B7-H7/HHLA2
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human B7-H7/HHLA2 Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human B7-H7 is greater than 95% as determined by SEC-HPLC.
Immobilized Human CD28H, His Tag at 2µg/ml (100µl/well) on the plate. Dose response curve for Human B7-H7, hFc Tag with the EC<,sub>,50<,/sub>, of 0.15µg/ml determined by ELISA.
Human B7-H7, hFc Tag captured on CM5 Chip via Protein A can bind Human KIR3DL3, His Tag with an affinity constant of 334 nM as determined in SPR assay (Biacore T200).
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