Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.
95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
Target:
IL-31RA
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human IL-31RA Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human IL-31 RA is greater than 95% as determined by SEC-HPLC.
Human IL-31, His Tag immobilized on CM5 Chip can bind Human IL-31 RA, His Tag with an affinity constant of 82.4nM as determined in a SPR assay (Biacore T200).
Immobilized Human IL-31 RA, His Tag at 0.5µg/ml (100µl/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC<,sub>,50<,/sub>, of 6.5ng/ml determined by ELISA.
* VAT and and shipping costs not included. Errors and price changes excepted
