FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes, its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy).
95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
Target:
FOLR2
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human FR-beta/FOLR2 Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human FOLR2 is greater than 95% as determined by SEC-HPLC.
Immobilized Human FOLR2, His Tag at 0.2µg/ml (100µl/well) on the plate. Dose response curve for Anti-FOLR2 Antibody, hFc Tag with the EC<,sub>,50<,/sub>, of 11.7ng/ml determined by ELISA.
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