Among inflammatory mediators, a growing body of evidence emphasizes the contribution of the interleukin 17 (IL-17) cytokine family in malignant diseases. Besides IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. In mouse models, IL-17B signaling through IL-17RB directly promotes cancer cell survival, proliferation, and migration, and induces resistance to conventional chemotherapeutic agents.
95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
Target:
IL-17RB
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human IL-17RB Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human IL-17RB is greater than 95% as determined by SEC-HPLC.
Immobilized Human IL-17RB, His Tag at 0.2µg/ml (100µl/well) on the plate. Dose response curve for Anti-IL-17RB Antibody, hFc Tag with the EC<,sub>,50<,/sub>, of 4.4ng/ml determined by ELISA.
Human IL-17RB, His Tag immobilized on CM5 Chip can bind Human IL-25, His Tag with an affinity constant of 0.81 nM as determined in SPR assay (Biacore T200).
Immobilized Human IL-17RB, His Tag at 5µg/ml (100µl/well) on the plate. Dose response curve for Biotinylated Human IL-25, His Tag with the EC<,sub>,50<,/sub>, of 58.5ng/ml determined by ELISA.
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