Recombinant Human Annexin A2/ANXA2 Protein, E. coli
Biozol Catalog Number:
ABB-RP02731
Supplier Catalog Number:
RP02731
Alternative Catalog Number:
ABB-RP02731-100UG
Manufacturer:
ABclonal
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Immunogen:
Ser2-Asp339
Alternative Names:
Chromobindin-8, Lipocortin II, PAP-IV, ANX2, ANX2L4, CAL1H, LPC2D, ANXA2, Annexin A2, Annexin II, LIP2PAP-IV, LPC2D, LPC2DP36, p36
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles. ResearchArea: Other Recombinant Protein
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