Biotinylated Recombinant Human P53 WT (HLA-A*02:01) Complex Protein

Product Overview

• Article Name: Biotinylated Recombinant Human P53 WT (HLA-A*02:01) Complex Protein
• Biozol Catalog Number: ABB-RP02756
• Supplier Catalog Number: RP02756
• Alternative Catalog Number: ABB-RP02756-100UG
• Manufacturer: ABclonal
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Immunogen: Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and HMTEVVRRC peptide
• Alternative Names: MHC, HLA-A, P53, TP53, Antigen NY-CO-13, BCC7, FLJ92943, LFS1, TRP53

Product Description

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

Product Properties

• Concentration: < 1 EU/µg of the protein by LAL method.
• Molecular Weight: 50.5 kDa
• UniProt: A0A140T913
• Purity: 95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
• Target: P53 WT (HLA-A*02:01) Complex

Application Notes

• Application Notes: Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles. ResearchArea: Other Recombinant Protein