Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
Lyophilized from a 0.22 µm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 2 mM DTT, pH 7.5.
Target:
Hepcidin/HAMP
Application Dilute:
Lyophilized from a 0.22 µm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 2 mM DTT, pH 7.5.
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Mouse Hepcidin/HAMP Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
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