GAS6, AXLLG,Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand
GAS-6 is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest . Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively gamma -carboxylated N-terminal Gla domain, four EGF-like repeats, and a C-terminal region with homology to steroid hormone binding globulin (SHBG) . Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer . Human Gas6 interacts with both mouse and rat orthologs of these receptors . The full length isoform may be cleaved, resulting in release of the free SHBG region which can independently activate Axl . Shed soluble forms of Axl and Mer bind Gas6 and function as decoy receptors . Gas6 induces a variety of responses, including prevention of apoptosis , cell proliferation , platelet-mediated thrombosis , retinal epithelial cell phagocytosis of outer rod segments , inhibition of VEGF-induced endothelial cell chemotaxis , and the differentiation and expansion of NK cell precursors . The affinity of Gas6 for phosphatidylserine likely contributes to its role in promoting the phagocytosis of apoptotic cells . Several of these effects have been shown to require gamma -carboxylation of the Gla domain .
Lyophilized from a 0.22 µm filtered solution of PBS, pH 7.4.
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles. ResearchArea: Cytokines & Cytokine receptors
* VAT and and shipping costs not included. Errors and price changes excepted
