Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinsons disease clinical trial and in a number of animal trials. It has been taken as a potent survival factor for central motoneurons.
Supplied as a 0.22 µm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4. Contact us for customized product form or formulation.
Target:
GDNF
Application Dilute:
Supplied as a 0.22 µm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4. Contact us for customized product form or formulation.
Application Notes:
Cross-Reactivity: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Cytokines & Cytokine receptors,Growth Factor,Cell Culture related
Recombinant Rat GDNF Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
* VAT and and shipping costs not included. Errors and price changes excepted
