F3, Cf-3, Cf3,Tissue factor, TF, Coagulation factor III, CD142
Tissue Factor/TF, also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling.
Lyophilized from a 0.2 µm filtered solution of 20mM Tris-HCl, 150mM NaCl, 0.05% Brij35, pH 7.5.
Target:
F3, Cf-3, Cf3
Application Dilute:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris-HCl, 150mM NaCl, 0.05% Brij35, pH 7.5.
Application Notes:
Cross-Reactivity: Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100µg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Mouse Tissue Factor/TF Protein was determined by reducing SDS-PAGE.
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