Monoclonal antibody to Bi-1 (Clone: ABM20E4), Clone: [ABM20E4], Mouse
Biozol Catalog Number:
ABI-10-1044-25
Supplier Catalog Number:
10-1044-25
Alternative Catalog Number:
ABI-10-1044-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.
Alternative Names:
TMBIM6||BI1||TEGT
Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased, however, up-regulated expression of this protein has been linked to increased cell proliferations.
