Monoclonal Antibody to Cytochrome C (Clone: ABM30D4), Clone: [ABM30D4], Mouse
Biozol Catalog Number:
ABI-10-1051
Supplier Catalog Number:
10-1051
Alternative Catalog Number:
ABI-10-1051-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Full length recombinant Cytochrome C protein was used as the immunogen for this antibody.
Alternative Names:
CYCS||CYC
Cytochrome C is an inner mitochondrial membrane hemeprotein encoded by CYCS gene. Cytochrome C has two major roles within the cell, firstly, it acts as an electron carrier between Complex III (Cytochrome bc1 complex) and Complex IV (Cytochrome C oxidase). The second important function of Cytochrome C is in apoptosis. In response to extrinsic or intrinsic signals and upon suppression of anti-apoptotic molecules, several pro-apoptotic molecules are activated that disturb the mitochondrial membrane permeability and causes the release of Cytochrome C. Cytochrome C then binds to apoptotic protease activating factor-1 (Apaf-1). This complex interacts with pro-caspase 9 and initiates the caspase cascade resulting in apoptosis. Human Cytochrome C has a molecular mass of 11 kDa. Defect in the CYCS gene is associated with autosomal dominant diseases like thrombocytopenia type 4 (THC4). High levels of Cytochrome C are found in blood leukocytes, kidney, liver, heart and brain.
