Monoclonal Antibody to 14-3-3 Theta (Clone: ABM52H6), Clone: [ABM52H6], Rat
Biozol Catalog Number:
ABI-10-1058-25
Supplier Catalog Number:
10-1058-25
Alternative Catalog Number:
ABI-10-1058-25-25UG
Manufacturer:
Abeomics
Host:
Rat
Category:
Antikörper
Application:
WB
Species Reactivity:
Mouse
Immunogen:
Full length recombinant protein of 14-3-3 Theta was used as the immunogen for this antibody.
Alternative Names:
14-3-3 protein tau
14-3-3 Theta, a member of 14-3-3 family, is an adapter protein that plays an important role in a wide range of vital regulatory processes, including signal transduction, apoptosis, cell cycle progression and DNA replication. Humans have seven 14-3-3 isoforms (beta, gamma, epsilon, eta, sigma, theta and zeta) that serve as scaffolds to promote interactions of regulatory phospho-proteins involved in many vital cellular processes. 14-3-3 Theta binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif, resulting in the modulation of the activity of the binding partner except PDPK1, whose kinase activity is negatively regulated. Previous studies have shown that disturbances in native 14-3-3 levels can contribute significantly to the development of various cancers. In lung cancer biopsies, 14-3-3 Theta is found to be present in abundance.
