Recombinant Anti-TNFa (Adalimumab biosimilar) mAb, Monoclonal

Product Overview

• Article Name: Recombinant Anti-TNFa (Adalimumab biosimilar) mAb, Monoclonal
• Biozol Catalog Number: ABI-10-2008
• Supplier Catalog Number: 10-2008
• Alternative Catalog Number: ABI-10-2008-100UG
• Manufacturer: Abeomics
• Category: Antikörper
• Application: ELISA, WB
• Alternative Names: Cachectin, TNF-alpha, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2 (TNF-a)

Product Description

SOURCE: Chinese Hamster Ovary Cells (CHO). Adalimumab belongs to the pharmacotherapeutic group -immunosuppressants, tumour necrosis factor alpha (TNF-alpha) inhibitors- (ATC code: L04AB04). The mechanism of action of adalimumab is binding specifically to TNF-alpha and neutralising its biological function by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab is a recombinant human IgG1 monoclonal antibody composed of two kappa light chains each with a molecular weight of approximately 24 kilo Daltons (kDa) and two IgG1 heavy chains each with a molecular weight of approximately 49 kDa based on the amino acid sequence. The total molecular weight of adalimumab with post-translational modifications is approximately 148 kDa. Each light chain consists of 214 amino acid residues and each heavy chain consists of 451 amino acid residues resulting in a total of 1330 amino acids for the entire IgG1 molecule, one glycosylation site (N301) is present. The primary amino-acid sequence of the heavy and light chains is reported.

Product Properties

• Clonality: Monoclonal
• NCBI: 7124
• UniProt: P01375
• Purity: Greater than 98.0% as determined by SDS-PAGE.
• Target: Adalimumab