Monoclonal Antibody to TLR3 (Clone: ABM15D5), Clone: [ABM15D5], Mouse
Biozol Catalog Number:
ABI-10-3004-25
Supplier Catalog Number:
10-3004-25
Alternative Catalog Number:
ABI-10-3004-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS
Species Reactivity:
Human
Immunogen:
A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
Alternative Names:
TLR3
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
