Monoclonal Antibody to CLEC9A (Clone: ABM23H8), Clone: [ABM23H8], Mouse
Biozol Catalog Number:
ABI-10-4020-25
Supplier Catalog Number:
10-4020-25
Alternative Catalog Number:
ABI-10-4020-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
A partial length recombinant protein ( a.a 15-218) of CLEC9A was used as the immunogen for this antibody.
Alternative Names:
C-type lectin domain family 9 member A, CLEC9A
CLEC9A is a C-type lectin receptor involved in the sensing and presentation of antigens derived from necrotic cells. It is expressed on the surface of the mouse and human dendritic cell subsets specialized for the uptake and processing of material from dead cells. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. It possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase and can induce proinflammatory cytokine production. CLEC9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.
