Monoclonal Antibody to CD161 (Clone: ABM2D74)

Product Overview

• Article Name: Monoclonal Antibody to CD161 (Clone: ABM2D74)
• Biozol Catalog Number: ABI-10-4048
• Supplier Catalog Number: 10-4048
• Alternative Catalog Number: ABI-10-4048-100UG
• Manufacturer: Abeomics
• Host: Mouse
• Category: Antikörper
• Application: FACS, IHC, WB
• Species Reactivity: Human
• Immunogen: A full length human CD161 protein was used as the immunogen for this antibody.
• Alternative Names: KLRB1||CLEC5B||NKRP1A

Product Description

CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).

Product Properties

• Clonality: Monoclonal
• Clone Designation: [ABM2D74]
• NCBI: 3820
• UniProt: Q12918
• Purity: Protein G Chromatography
• Form: Purified
• Target: CD161

Application Notes

• Application Dilute: Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml FACS: 0.2-0.5 µg/10 6 cells

Images

Fig-1: Western blot analysis of CD161. Anti-CD161 antibody (Clone: ABM2D74) was tested at 2 µg/ml on Jurkat lysate.

Fig-4 : Cell Surface flow analysis of hCD161 in PBMC (Lymphocytes) using 0.2µg/10 6 cells of CD161 clone ( ABM2D74). Green represents isotype control, red represents anti-hCD161 antibody. Goat anti-mouse PE conjugated secondary antibody (ABEOMICS) was used.

Fig-2 : Immunohistochemical analysis of CD161 in small cell carcinoma of esophagus using CD161 antibody (Clone: ABM2D74) at 5 µg/ml.

Fig-3 : Immunohistochemical analysis of CD161in Transitional cell carcinoma of urinary bladder using CD161 antibody (Clone: ABM2D74) at 5 µg/ml.