Monoclonal Antibody to CD161 (Clone: ABM2D74), Clone: [ABM2D74], Mouse
Biozol Catalog Number:
ABI-10-4048
Supplier Catalog Number:
10-4048
Alternative Catalog Number:
ABI-10-4048-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IHC, WB
Species Reactivity:
Human
Immunogen:
A full length human CD161 protein was used as the immunogen for this antibody.
Alternative Names:
KLRB1||CLEC5B||NKRP1A
CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).
