Monoclonal Antibody to Dnmt1 (Clone: ABM13B2), Clone: [ABM13B2], Mouse
Biozol Catalog Number:
ABI-10-7002-25
Supplier Catalog Number:
10-7002-25
Alternative Catalog Number:
ABI-10-7002-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IHC, WB
Species Reactivity:
Human, Mouse
Immunogen:
A partial length recombinant DNMT1 protein (amino acids 128-429) was used as the immunogen for this antibody.
Alternative Names:
DNMT1||AIM||CXXC9||DNMT
Dnmt1(DNA (cytosine-5-)-methyltransferase 1 ) is one of the most abundant DNA methyltransferase in mammalian tissues, where it associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. Dnmt1 comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2). The C-terminal domains of mammalian Dnmts contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. Dnmt1 maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity. The molecules interacting with Dnmt1, including RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules are involved in chromatin organization, DNA repair, cell cycle regulation, and apoptosis.
