Monoclonal Antibody to DNMT2 (Clone: ABM1H70), Clone: [ABM1H70], Mouse
Biozol Catalog Number:
ABI-10-7010
Supplier Catalog Number:
10-7010
Alternative Catalog Number:
ABI-10-7010-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, WB
Species Reactivity:
Human, Mouse
Immunogen:
A partial length recombinant protein from DNMT2 was used as the immunogen for this antibody.
Alternative Names:
DNA (cytosine-5)-methyltransferase-like protein 2, DNA methyltransferase homolog HsaIIP, DNMT2
DNMT2, also known as tRNA-aspartic acid methyltransferase 1 (TRDMT1), is highly conserved cytosine-C5 methyltransferase that introduces the C38 methylation of tRNAAsp in many species, including lower eukaryotes, plants, insects, and humans. DNMT2 contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3 families. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
