Monoclonal Antibody to Desmoglein 3 (Clone: ABM4A31), Clone: [ABM4A31], Mouse
Biozol Catalog Number:
ABI-10-7539-25
Supplier Catalog Number:
10-7539-25
Alternative Catalog Number:
ABI-10-7539-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
A partial length recombinant Desmoglein 3 protein (amino acids 328-526) was used as the immunogen for this antibody.
Alternative Names:
DSG3||CDHF6
DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.
