Monoclonal Antibody to Human PD-L1 (Clone: ABM4E54) (BSA/AZIDE Free), Clone: [ABM4E54], Mouse
Biozol Catalog Number:
ABI-10-7562-BAF-25
Supplier Catalog Number:
10-7562-BAF-25
Alternative Catalog Number:
ABI-10-7562-BAF-25-25UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS, IHC, WB
Species Reactivity:
Human
Immunogen:
A partial length recombinant PDL1 protein (amino acids 18-227) was used as the immunogen for this antibody.
Alternative Names:
CD274||B7H1||PDCD1L1||PDCD1LG1||PDL1
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells, and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
