Monoclonal Antibody to Mouse PD-L1 (Clone: 10F.9G2), Clone: [10F.9G2], Rat
Biozol Catalog Number:
ABI-10-7648-25
Supplier Catalog Number:
10-7648-25
Alternative Catalog Number:
ABI-10-7648-25-25UG
Manufacturer:
Abeomics
Host:
Rat
Category:
Antikörper
Application:
FACS
Species Reactivity:
Mouse
Immunogen:
Mouse CD274
Alternative Names:
Programmed cell death 1 ligand 1, Programmed cell death 1 ligand 1, Programmed death ligand 1, B7-H1
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274/PD-L1 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
Figure 1: Cell surface staying of splenocytes stimulated with ConA + mIL2 for 3 days. Green represents Rat isotope control, red represents Anti-mouse PD-L1 (10-7648). 0.2 µg antibodies were used. Goat anti-rat PE was used as secondary antibody.
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