Monoclonal Antibody to MITF (Clone: ABM1H91), Clone: [ABM1H91], Mouse
Biozol Catalog Number:
ABI-10-8004
Supplier Catalog Number:
10-8004
Alternative Catalog Number:
ABI-10-8004-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse
Immunogen:
A partial length recombinant MITF protein (amino acids 150-427) was used as the immunogen for this antibody.
Alternative Names:
MITF||BHLHE32
MITF (Microphthalmia-associated transcription factor) is a basic helix-loop-helix leucine zipper (bHLH-Zip) family factor, involved in lineage-specific pathway regulation of many types of cells including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. It plays a critical role in melanogenesis as a transcriptional activator of tyrosinase, TRP-1, and TRP-2. Moreover, it regulates specification, survival, and proliferation of normal melanocytes, and controls proliferation, migration and invasion of melanoma cells. MITF is the most characterized member of the MIT family, mutations of which can lead to diseases such as Melanoma, Waardenburg syndrome, and Tietz syndrome.
