Polyclonal Antibody to SAPK interacting protein 1/Mip1, Rabbit
Biozol Catalog Number:
ABI-11-8022-25
Supplier Catalog Number:
11-8022-25
Alternative Catalog Number:
ABI-11-8022-25-25UG
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
A partial length recombinant Mip1 protein (amino acids 250-522) was used as the immunogen for this antibody.
Alternative Names:
MAPKAP1||MIP1||SIN1
Stress-activated map kinase (SAPK )-interacting protein 1, also called as Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1), belongs to Stress-activated map kinase interacting protein 1 (SIN1) family. It is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors and also plays a critical role in AKT1 Ser-473 phosphorylation. Except isoform 4 from its 6 isoforms , all can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. It is ubiquitously expressed in heart and skeletal muscle. Diseases associated with MAPKAP1 include bronchiolitis obliterans organizing pneumonia and nephrogenic systemic fibrosis.
