Full length recombinant Ngn3 protein was used as the immunogen for this antibody.
Alternative Names:
Class A basic helix-loop-helix protein 7, Protein atonal homolog 5, ATOH5, BHLHA7, NGN3
Neurog 3/Ngn 3 belongs to the bHLH (basic helix-loop-helix) class of transcription factors and functions primarily as an activator of gene transcription in endocrine progenitor cells. It is expressed in a small percentage of cells within the developing pancreas consisting of endocrine progenitor cells, and functions to directly enhance the expression of the lineage-committed transcription factors required for the differentiation of the endocrine progenitor cells into each of the endocrine cell subtypes. Ngn3 binds directly to the promoters of the beta -cell specific transcription factors beta2/NeuroD and Pax4 to promote the differentiation of progenitor cells into the b cell lineage. Ngn3 expression is extinguished coincident with the expression of the endocrine hormones that define the endocrine lineages, for example the insulin expression in beta cells. (21099270, 18599526)
