Recombinant Rabbit Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker)(Clone : NX2/1422R), Clone: [NX2/1422R]

Product Overview

• Article Name: Recombinant Rabbit Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker)(Clone : NX2/1422R), Clone: [NX2/1422R]
• Biozol Catalog Number: ABI-12-1032
• Supplier Catalog Number: 12-1032
• Alternative Catalog Number: ABI-12-1032-100UG
• Manufacturer: Abeomics
• Category: Sonstiges
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant human NKX2.2 protein fragment (exact sequence is proprietary)
• Alternative Names: Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman

Product Description

Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [NX2/1422R]
• NCBI: 4821
• UniProt: O95096
• Purity: Purified Ab with BSA and Azide at 200ug/ml
• Form: Purified
• Target: NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker)
• Antibody Type: Recombinant Antibody

Application Notes

• Application Dilute: Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes),