A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Conjugation:
FITC
Alternative Names:
Signal transducer and activator of transcription 6, IL-4 Stat
The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis, a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.
Clonality:
Monoclonal
Clone Designation:
[Stat6Y641-G12]
Form:
Conjugated
Application Dilute:
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
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