STAT5 Leeporter(TM) Luciferase Reporter-Ba/F3 Cell Line Preis auf Anfrage
Biozol Catalog Number:
ABI-14-135ACL
Supplier Catalog Number:
14-135ACL
Alternative Catalog Number:
ABI-14-135ACL-1VIAL
Manufacturer:
Abeomics
Category:
Zellen/Zellkultur
Application:
FA
The STAT5 Leeporter(TM) Luciferase Reporter cell line is a stably transfected Ba/F3 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the STAT5 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT5. As a transcription factor, Signal Transducer and Activator of Transcription 5 (STAT5) is activated through phosphorylation at tyrosine 694 in response to many cytokines and growth factors including IL-2, IL-3, GM-CSF and prolactin. Aberrant STAT5 activity is closely related to a wide range of human cancers as STAT5 is often found to be constitutively phosphorylated in cancer cells. The phosphorylated STAT5 forms homodimers or heterodimers with other STATs, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT5 induction by IL-3 is shown in Figure 1.
Application Dilute:
Application: Monitor the STAT5 signaling pathway activity. Screen for activators or inhibitors of the STAT5 signaling pathway. Culture conditions: Cells should be grown at 37C with 5% CO2 using RPMI medium supplemented with 10% heat-inactivated FBS, 1 mM
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