Molecular Characterization: CD112(Gln32-Gly360) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 61.4 kDa after removal of the signal peptide.The apparent molecular mass of CD112-hFc is approximately 70 kDa due to glycosylation.Description: Recombinant Human CD112 Protein with C-terminal human Fc tagThis gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
