Molecular Characterization: CCR4(Met1-Glu39)(Ala99-Lys111)(Ser176-Val200)(Val268-Tyr284) hFc(Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 37.1 kDa after removal of the signal peptide.The apparent molecular mass of CCR4-hFc is approximately 35-55 kDa due to glycosylation. Description: Recombinant Human CCR4 with C-terminal human Fc tag The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
