Molecular Characterization: CD26(Asn29-Pro766)6A-His tagMolecular weight: The protein has a predicted molecular mass of 111.5 kDa after removal of the signal peptide.The apparent molecular mass of CD26-His is approximately 100-130 kDa due to glycosylation.Description: Recombinant Human CD26 with C-terminal6A-His tagThe DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19.
