Recombinant Human SCUBE2(441-659) Protein, hFc Tag
Biozol Catalog Number:
ABI-32-17840
Supplier Catalog Number:
32-17840
Alternative Catalog Number:
ABI-32-17840-50UG
Manufacturer:
Abeomics
Host:
Human
Category:
Proteine/Peptide
Alternative Names:
CEGP1, Scube/You
Molecular Characterization: SCUBE2(Asp441-Asn659 ) hFc(Glu99-Ala330)Molecular weight: The protein has a predicted molecular mass of 50.2 kDa after removal of the signal peptide. The apparent molecular mass of SCUBE2(441-659)-hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant human SCUBE2(441-659) protein with C-terminal human Fc tagLipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed: 22902404, PubMed: 22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed: 24522195). Synergizes with DISP1 to increase SHH secretion (PubMed: 22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed: 27834687).[UniProtKB/Swiss-Prot Function]
